发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING CB1 CANNABINOID RECEPTOR ANTAGONISTS AND POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF DIABETES MELLITUS TYPE I, OBESITY AND RELATED CONDITIONS |
摘要 |
Described is a novel combination therapy for diabetes mellitus type I and/or for obesity and its concomitant and/or secondary diseases or conditions, in particular the metabolic syndrome and/or syndrome X, and/or diabetes mellitus type II, by administering a combination of at least one K<SUB>ATP </SUB>channel opener as a first active agent and at least one CB1 cannabinoid receptor antagonist as a second active agent. The invention is further directed to such novel combination therapy wherein a dually acting compound with combined KATP channel opening and CB<SUB>1</SUB> antagonistic properties is used. The invention also relates to novel pharmaceutical compositions comprising K<SUB>ATP</SUB> channel openers and CB1 antagonists and the use of said pharmaceutical compositions in the treatment, delayed progression, delayed onset of and/or inhibition of diabetes mellitus type I, and the prophylaxis and treatment, of obesity as well as the prophylaxis, treatment, delayed onset and/or inhibition of its concomitant and/or secondary diseases or conditions, in particular the metabolic syndrome and/or syndrome X, and/or diabetes mellitus type II, in mammals and humans. The invention is further directed to such novel pharmaceutical compositions comprising a dually acting compound with combined K<SUB>ATP</SUB> channel opening and CB<SUB>1</SUB> antagonistic properties. |
申请公布号 |
WO2006045799(A2) |
申请公布日期 |
2006.05.04 |
申请号 |
WO2005EP55534 |
申请日期 |
2005.10.25 |
申请人 |
SOLVAY PHARMACEUTICALS GMBH;FIRNGES, MICHAEL;GREGORY, PETER-COLIN;ANTEL, JOCHEN;LANGE, JOSEPHUS HUBERTUS MARIA;WALDECK, HARALD |
发明人 |
FIRNGES, MICHAEL;GREGORY, PETER-COLIN;ANTEL, JOCHEN;LANGE, JOSEPHUS HUBERTUS MARIA;WALDECK, HARALD |
分类号 |
A61K31/00;A61K31/40;A61K31/415;A61K31/427;A61K31/44;A61K31/54;A61P3/04;C12Q1/68;G01N33/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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