发明名称 |
SALT OF A SULFONIC ACID CONTAINING CLOPIDOGREL AND USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICAL FORMULATIONS |
摘要 |
Clopidogrel benzenesulfonate salt (I) which is either at least partly in crystalline form or is produced by precipitation from a solution of clopidogrel in toluene and/or dioxane, is new. Independent claims are also included for: (1) production of (I) by precipitation from a solution of clopidogrel in toluene and/or dioxane; (2) purifying clopidogrel by converting impure clopidogrel or a salt thereof to (I) and optionally releasing clopidogrel base from the isolated (I) and optionally converting it to another salt; (3) particles comprising (I) adsorbed on a solid adsorbent; (4) production of the particles by recovering them from a solvent in which the adsorbent in insoluble and (I) is soluble. ACTIVITY : Anticoagulant; Cerebroprotective; Cardiant. MECHANISM OF ACTION : Platelet aggregation inhibitor. |
申请公布号 |
PL378572(A1) |
申请公布日期 |
2006.05.02 |
申请号 |
PL20040378572 |
申请日期 |
2004.02.13 |
申请人 |
HELM AG |
发明人 |
DOSER KARLHEINZ;GLAENZER KLAUS |
分类号 |
C07D495/04;A61K9/14;A61K31/435;A61K31/4743;C07C309/29;C07D498/02 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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