发明名称 |
BENZOXAZEPINE COMPOUND |
摘要 |
A compound represented by the formula [1]:
wherein ring A and ring B each represent an optionally substituted benzene ring; ring C represents an optionally further substituted aromatic ring; R 1 represents a lower alkyl group optionally substituted with an optionally substituted hydroxyl group; X 1a represents a bond or optionally substituted lower alkylene; X 1b represents a bond or optionally substituted lower alkylene; X 2 represents a bond, -O- or -S-; X 3 represents a bond or an optionally substituted divalent hydrocarbon group; Y represents an optionally esterified or amidated carboxyl group, or a salt thereof. The compound of the formula [I] is safer and has more potent lipid lowering activity such as squalene synthase inhibitory activity (cholesterol lowering activity) and triglyceride lowering activity, and thus it is a compound useful as an agent for preventing or treating hyperlipemia.
|
申请公布号 |
EP1650201(A1) |
申请公布日期 |
2006.04.26 |
申请号 |
EP20040748264 |
申请日期 |
2004.07.30 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
MARUI, SHOGO;MIKI, TAKASHI;MIURA, SHOUTAROU;NISHIMOTO, TOMOYUKI;NAKADA, YOSHIHISA |
分类号 |
A61P1/18;A61P3/00;A61P3/06;A61P3/10;A61P5/14;A61P7/00;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P13/12;A61P19/00;A61P19/10;A61P21/00;A61P25/28;A61P43/00;C07D417/06;(IPC1-7):C07D267/14 |
主分类号 |
A61P1/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|