摘要 |
The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C<SUB>3-14 </SUB>hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula -CO-, etc.; X indicates a single bond, an oxygen atom etc.; R<SUP>1 </SUP>indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D<SUP>1</SUP>, D<SUP>2</SUP>, W<SUP>1 </SUP>and W<SUP>2 </SUP>are the same as or different from each other and each represents a single bond or an optionally substituted C<SUB>1-6 </SUB>alkylene chain.
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