发明名称 |
RECOMBINANT BIFUNCTIONAL PROTEIN OF HUMAN LUTROPIN RECEPTOR AND HUMAN CHORIONIC GONADOTROPIN B-SUBUNIT AND USES THEREOF |
摘要 |
<p>The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-ß subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropin- ß fusion protein, and antibodies which recognize part or all the domains of the fusion protein. Also provided are compositions having the human lutropin hormone-receptor/human chorionic gonadotropin-ß fusion protein and a pharmaceutical carrier and compositions including antibodies to the fusion protein and a pharmaceutical carrier. The present invention also relates to methods of treating androgen-excess-mediated disease conditions by administering to a subject an antibody to the human lutropin hormone-receptor/human chorionic gonadotropin-ß fusion protein under conditions suitable to treat the conditions, and methods of immunocontraception that involve administering to a subject the chimeric nucleic acid molecule encoding the human lutropin hormone receptor/human chorionic gonadotropin-ß fusion protein, the fusion protein in whole or in part, or antibodies thereto.</p> |
申请公布号 |
WO2006036877(A2) |
申请公布日期 |
2006.04.06 |
申请号 |
WO2005US34386 |
申请日期 |
2005.09.26 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
SAXENA, BRIJ, B.;RATHNAM, PREMILA;SINGH, MUKUL;HAO, MEIRONG |
分类号 |
C07H21/04;C07K14/59 |
主分类号 |
C07H21/04 |
代理机构 |
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