摘要 |
We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I), wherein: R<SUP>5</SUP> is OH, alkoxy or alkanoyloxy; R<SUP>6</SUP> is hydrogen, alkyl, alkenyl, alkynyl or aryl; R<SUP>12</SUP> is hydrogen, alkyl, alkenyl, alkynyl or aryl; R<SUP>16</SUP> is hydrogen, alkyl, alkenyl, alkynyl or aryl; R<SUP>17</SUP> is OH, alkoxy or alkanoyloxy; R<SUP>18</SUP> is OH, alkoxy or alkanoyloxy; R<SUP>21</SUP> is H, OH, CN or another nucleophilic group; and R<SUP>a</SUP> is hydrogen and R<SUP>b</SUP> is optionally substituted amino, or R<SUP>a</SUP> with R<SUP>b</SUP> form a carbonyl function =O, or R<SUP>a</SUP>, R<SUP>b</SUP> and the carbon to which they are attached form a tetrahydroisoquinoline group. |
申请人 |
PHARMA MAR S.A., SOCIEDAD UNIPERSONAL;RUFFLES, GRAHAM, KEITH;ALLAVENA, PAOLA;D'INCALCI, MAURIZIO;FAIRCLOTH, GLYNN, THOMAS |
发明人 |
ALLAVENA, PAOLA;D'INCALCI, MAURIZIO;FAIRCLOTH, GLYNN, THOMAS |