摘要 |
Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass. Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient by administering a kalliekrein inhibitor. |
申请人 |
DYAX CORP.;LADNER, ROBERT, C.;LEY, ARTHUR, C.;HIRANI, SHIRISH;WILLIAMS, ANTHONY;DE SIMONI, MARIA, GRAZIA;BERGAMASCHINI, LUIGI;BLAIR, HENRY;BECK, THOMAS |
发明人 |
LADNER, ROBERT, C.;LEY, ARTHUR, C.;HIRANI, SHIRISH;WILLIAMS, ANTHONY;DE SIMONI, MARIA, GRAZIA;BERGAMASCHINI, LUIGI;BLAIR, HENRY;BECK, THOMAS |