发明名称 |
Combination of an aromatase inhibitor with a bisphosphonate |
摘要 |
The present invention provides a combination for the treatment of a disease or condition which responds to aromatase inhibition, in particular a proliferative disease, especially a malignant disease such as breast cancer or similar soft tissue endocrine-sensitive cancer, most preferably breast cancer, comprising an aromatase inhibitor and a bisphosphonate for simultaneous, concurrent, separate or sequential use in the prevention of bone loss which is caused by the treatment with an aromatase inhibitor. Also provided is a method of treating a patient suffering from a disease or condition which responds to aromatase inhibition comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an aromatase inhibitor.
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申请公布号 |
US2006069067(A1) |
申请公布日期 |
2006.03.30 |
申请号 |
US20050521928 |
申请日期 |
2005.01.21 |
申请人 |
BHATNAGAR AJAY S;EVANS DEAN B;GASSER JURG A;GREEN JONATHAN |
发明人 |
BHATNAGAR AJAY S.;EVANS DEAN B.;GASSER JURG A.;GREEN JONATHAN |
分类号 |
A61K31/675;C07D249/08;A61K31/35;A61K31/4164;A61K31/4196;A61K31/44;A61K31/56;A61K31/663;A61K45/00;A61K45/06;A61P19/08;A61P35/00;A61P43/00 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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