| 摘要 |
<p>The invention relates to 5-HT receptor modulators, particularly 5-HT<SUB>2B</SUB> antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds, and uses thereof for treating conditions including pulmonary arterial hypertension, congestive heart failure, hypertension, central nervous system disorders such as migraine, disorders of the gastrointestinal tract, restenosis, asthma, obstructive airway disease, prostatic hyperplasia and priapism, anxiety, depression, schizophrenia, neural injury and stroke. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also provided.</p> |
| 申请人 |
PREDIX PHARMACEUTICALS HOLDINGS, INC.;DHANOA, DALE, S.;BECKER, OREN;NOIMAN, SILVIA;ALLA, SEKAR, REDDY;MELENDEZ, ROSA, E.;SHARADENDU, ANURAG;CHEN, DONGLI;MARANTZ, YAEL;SHACHAM, SHARON;HEIFETZ, ALEXANDER;INBAL, BOAZ;KESAVAN, VENKITASAMY;BAR-HAIM, SHAY;CHERUKU, SRINIVASA, RAO |
发明人 |
DHANOA, DALE, S.;BECKER, OREN;NOIMAN, SILVIA;ALLA, SEKAR, REDDY;MELENDEZ, ROSA, E.;SHARADENDU, ANURAG;CHEN, DONGLI;MARANTZ, YAEL;SHACHAM, SHARON;HEIFETZ, ALEXANDER;INBAL, BOAZ;KESAVAN, VENKITASAMY;BAR-HAIM, SHAY;CHERUKU, SRINIVASA, RAO |
