发明名称 Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
摘要 A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound is chelated to a medically active material that generates a signal for diagnostic imaging or produces a therapeutic effect at the site of the marker substance. A method for detecting, diagnosing, and/or treating a disease that produces the marker substance uses a conjugate comprising the multifunctional cross-bridged tetraaza macrocyclic compound.
申请公布号 US2006062728(A1) 申请公布日期 2006.03.23
申请号 US20040947112 申请日期 2004.09.23
申请人 GENERAL ELECTRIC COMPANY 发明人 BROGAN JOHN B.
分类号 A61K51/00;C07F5/00 主分类号 A61K51/00
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