METHODS AND SYSTEMS FOR TREATMENT OF NEUROLOGICAL DISEASES OF THE CENTRAL NERVOUS SYSTEM
摘要
The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes of proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.
申请公布号
WO2005089462(A3)
申请公布日期
2006.03.23
申请号
WO2005US09022
申请日期
2005.03.17
申请人
MEDTRONIC, INC.;KEIMEL, JOHN, G.;KAEMMERER, WILLIAM, F.