IDENTIFICATION OF NOVEL TARGETS FOR RADIO SENSITIZATION USING A GENOMIC-BASED RADIATION SENSITIVITY CLASSIFIER

摘要

A classifier to predict cellular radiation sensitivity based on gene expression profiles in thirty-five cell lines from the NCI panel of 60 cancer cell lines (NCI-60), using a novel approach to predictive gene analysis. Three novel genes are provided, retinoblastoma binding protein 4 (RbAp48), G-protein signaling regulator 19 (RGS 19) and ribose-5-phosphate isomerase A (R5PIA) whose expression values were correlated with radiation sensitivity.