Compounds which inhibit the release of inflammatory cytokines

摘要

The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula:wherein R comprises ethers or amines;R<1 >is:a) substituted or unsubstituted aryl; orb) substituted or unsubstituted heteroaryl;R<2a >and R<2b >units are each independently hydrogen, ethers, amines, amides, carboxylates, or said units can form a double bond, a carbonyl, or R<2a >and R<2b >can be taken together to form a substituted or unsubstituted ring comprising from 4 to 8 atoms, said ring selected from the group consisting of:i) carbocyclic;ii) heterocyclic;iii) aryl;iv) heteroaryl;v) bicyclic; andvi) heterobicyclic.