发明名称 |
PROCESS FOR PREPARING PYRROLOTRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS |
摘要 |
A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong organometallic base, such as hexyllithium or n-butyllithium and the desired amine such as n-propylamine to form the amide II.
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申请公布号 |
US2006035886(A1) |
申请公布日期 |
2006.02.16 |
申请号 |
US20050199746 |
申请日期 |
2005.08.09 |
申请人 |
CANN REGINALD O;DELANEY EDWARD J;FAN JUNYING;PARLANTI LUCA |
发明人 |
CANN REGINALD O.;DELANEY EDWARD J.;FAN JUNYING;PARLANTI LUCA |
分类号 |
A61K31/551;A61K31/53;C07D487/04 |
主分类号 |
A61K31/551 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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