| 发明名称 |
HIGH AFFINITY ANTI-TNF-ALPHA ANTIBODIES AND METHOD |
| 摘要 |
<p>An isolated human anti-TNF-alpha antibody, or antigen-binding portion thereof, containing at least one high-affinity V<SUB>L </SUB>or V<SUB>H </SUB>antibody chain that is effective, when substituted for the corresponding V<SUB>L </SUB>or V<SUB>H </SUB>chain of the anti-TNF-alpha scFv antibody having sequence SEQ ID NO: 1, to bind to human TNF-alpha with a K<SUB>off </SUB>rate constant that is at least 1.5 fold lower than that of the antibody having SEQ ID NO: 1, when determined under identical conditions.</p> |
| 申请公布号 |
CA2573259(A1) |
申请公布日期 |
2006.02.09 |
| 申请号 |
CA20052573259 |
申请日期 |
2005.07.06 |
| 申请人 |
BIOREN INC. |
发明人 |
RAJPAL, ARVIND;CAPPUCCILLI, GUIDO;JONES, JENNIFER;TAKEUCHI, TOSHI;CREA, ROBERTO |
| 分类号 |
C07K16/24;A61K39/395 |
主分类号 |
C07K16/24 |
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