MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE
摘要
The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
申请公布号
WO2004005525(A3)
申请公布日期
2006.02.02
申请号
WO2003US21305
申请日期
2003.07.03
申请人
BASF AKTIENGESELLSCHAFT;YOCUM, R., ROGERS;PATTERSON, THOMAS, A.;PERO, JANICE, G.;HERMANN, THERON
发明人
YOCUM, R., ROGERS;PATTERSON, THOMAS, A.;PERO, JANICE, G.;HERMANN, THERON