发明名称 Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
摘要 The invention pertains to theophylline (1-methyl, 3-methyl xanthine) and IBMX (1-methyl, 3-isobutyl xanthine) derivatives of formulas I and II: where R<SUB>1 </SUB>is -CH<SUB>3 </SUB>or -CH<SUB>2</SUB>CH(CH<SUB>3</SUB>)<SUB>2</SUB>, and R<SUB>2 </SUB>is where R<SUB>3 </SUB>and R<SUB>4 </SUB>are independently selected from the group consisting of OCH<SUB>3</SUB>, CH<SUB>3</SUB>, NO<SUB>2</SUB>, F, Cl, Br and I.
申请公布号 US6979687(B1) 申请公布日期 2005.12.27
申请号 US20020256115 申请日期 2002.09.27
申请人 CHO-JAN LIANG 发明人 CHEN ING-JUN
分类号 A61K31/522;A61P15/10;C07D473/04;C07D473/06;C07D473/08;(IPC1-7):A61P15/10 主分类号 A61K31/522
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