发明名称 |
LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF |
摘要 |
<p>Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR<6>-; n is an integer from 2 to 4; R<5> is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl; and when Q is -X--CO-, R5 is further selected from alkoxy, substituted alkoxy, cycloalkoxy, and substituted cycloalkoxy.</p> |
申请公布号 |
WO2005121069(A1) |
申请公布日期 |
2005.12.22 |
申请号 |
WO2005US19492 |
申请日期 |
2005.06.03 |
申请人 |
XENOPORT, INC.;XIANG, JIA-NING;GALLOP, MARK, A.;ZHOU, CINDY, X.;NGUYEN, MARK;DAI, XUEDONG;LI, JIANHUA;CUNDY, KENNETH, C.;JUMBE, NELSON, L. |
发明人 |
XIANG, JIA-NING;GALLOP, MARK, A.;ZHOU, CINDY, X.;NGUYEN, MARK;DAI, XUEDONG;LI, JIANHUA;CUNDY, KENNETH, C.;JUMBE, NELSON, L. |
分类号 |
A61K31/216;A61K31/235;A61K31/24;A61K31/277;A61K31/4409;A61K31/455;A61K31/609;A61K31/618;A61P25/16;C07C229/34;C07C229/36;C07C235/48;C07C235/60;C07C255/59;C07D213/79;C07D213/80;(IPC1-7):C07C229/36;A61K31/440 |
主分类号 |
A61K31/216 |
代理机构 |
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代理人 |
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