发明名称 |
Vectors and methods for gene transfer |
摘要 |
The present invention provides a recombinant adenovirus comprising coat proteins that lack native binding. In particular, the present invention provides a recombinant adenovirus comprising a penton base protein and a fiber protein, wherein the penton base protein and the fiber protein lack native binding. The present invention further provides a recombinant adenovirus comprising (a) a penton base protein that lacks native binding and (b) a nonnative amino acid sequence that binds a cell-surface binding site.
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申请公布号 |
US2005277193(A1) |
申请公布日期 |
2005.12.15 |
申请号 |
US20050155845 |
申请日期 |
2005.06.17 |
申请人 |
GENVEC, INC. |
发明人 |
WICKHAM THOMAS J.;KOVESDI IMRE;BROUGH DOUGLAS E. |
分类号 |
A61K38/00;A61K48/00;C07K14/075;C07K14/705;C12N1/21;C12N7/00;C12N15/861;C12N15/866;C12N15/87;(IPC1-7):C12N1/21 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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