| 摘要 |
<p>There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4 --quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula, wherein R is alkyl(C,-C3) prepared by reacting a substituted anthranilate with N,N -dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t -butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2 -carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2 - carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4 -quinolone.</p> |
