PARTICULATE COMPRISING A CALCIUM-CONTAINING COMPOUND AND A SUGAR ALCOHOL

摘要

The present invention relates to a particulate material and a solid dosage
form notably tablets comprising a regularly shaped calcium-containing compound
such as a calcium salt as a therapeutically and/or prophylactically active
substance and a pharmaceutically acceptable sugar alcohol such as, e.g.,
sorbitol and/or isomalt that has a micro structure as evidenced by SEM. The
invention also relates to a process for the preparation of the particulate
material and solid dosage form. The process involves agglomeration of the
calcium-containing compound and the pharmaceutically acceptable sugar alcohol
by means of roller compaction. The particulate material obtained by roller
compaction is suitable for use in the further processing of the particulate
material into e.g. tablets such as chewing tablets.