发明名称 |
Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
摘要 |
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
|
申请公布号 |
US2005261353(A1) |
申请公布日期 |
2005.11.24 |
申请号 |
US20050064758 |
申请日期 |
2005.02.24 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
NUGIEL DAVID A.;CARINI DAVID J.;DI MEO SUSAN V.;VIDWANS ANUP P.;YUE EDDY |
分类号 |
A61K31/4162;C07D231/54;C07D401/04;C07D401/12;C07D403/04;C07D405/04;C07D409/04;C07D409/12;C07D409/14;(IPC1-7):A61K31/416 |
主分类号 |
A61K31/4162 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|