T-TYPE CALCIUM CHANNEL SPLICE VARIANT COMPOSITIONS AND METHODS

摘要

Cell proliferative conditions are associated with expression of a previously unknown Cav3.1 T-type calcium channel splice variant, Cav3.1ac. Also, it has been determined that the Cav3.1ac T-type splice variant interacts with annexin III (ANX III). This interaction is useful in identifying substances to treat cell proliferation. Also, diagnostics and prognostics of cell proliferative disorders and methods for treating such disorders are disclosed.