SOLUTION CONTAINING IGF-1

摘要

The invention relates to solutions containing IGF-1 or any functional analog ue thereof in which pH is 5.5 to 6.5, preferably 5.7 to 6.2. The amount of phosphate as buffer substance should be in a concentratio n of less than 50 mmol/L. Preferably the formulation is an aqueous solution of IGF-1 and phosphate as buffer substance in a concentrati on of 5 to 50 mmol/L or more preferably 5-20 mmol/L,, e.g. mmol/L. The solution should be isotonic. The solution gives a reduced pain upon subcutaneous injection. The invention also relates to a process for preparation of the formulation by mixing IGF-1 or any functional analogue thereof with a buffer substance giving pH 5.5 to 6.5 and an isotonic agent. It also relates to a method for treatment of a patient in need of IGF-1 or any functional analogue thereof by administering the claimed formulation.