DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR GPR34 (GPR34)

摘要

The invention provides a human GPR34 which is associated with the cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, gastrointestinal and liver diseases, cancer disorders, metabolic diseases, inflammatory diseases, hematological disorders, muscle-skeleton disorders, neurological disorders, urological disorders, respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, gastrointestinal and liver diseases, cancer disorders, metabolic diseases, inflammatory diseases, hematological disorders, muscle-skeleton disorders, neurological disorders, urological disorders, respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR34 as well as pharmaceutical compositions comprising such compounds.