发明名称 |
Transcriptional mediators of blood vessel development and endothelial differentiation |
摘要 |
This invention relates to methods of modulating the development of blood vessels and/or endothelial cell differentiation in a mammal comprising altering the activity of an Ets transcription factor, which activates vascular specific genes. More particularly, the transcription factor comprises ELF-1, and transcription factors that are homologous to ELF-1. The invention further relates to methods of screening for compounds that affect the activity of these transcription factors, and therefore, affect the development of blood vessels and/or endothelial cell differentiation. The invention also relates to methods of using these compounds to treat diseases, or symptoms of diseases, by either increasing or decreasing blood vessel development and/or endothelial cell differentiation.
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申请公布号 |
US6960444(B2) |
申请公布日期 |
2005.11.01 |
申请号 |
US20030446468 |
申请日期 |
2003.05.28 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
OETTGEN PETER;LIBERMANN TOWIA |
分类号 |
C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K38/53;A61K45/00;A61K48/00;A61P1/04;A61P3/10;A61P9/00;A61P9/10;A61P17/06;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C07K14/465;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/02;C12Q1/68;(IPC1-7):G01N33/53;C07K14/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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