发明名称 |
METHOD OF REDUCING C-REACTIVE PROTEIN USING GROWTH HORMONE SECRETAGOGUES |
摘要 |
<p>The present invention relates to a method of reducing C-reactive protein in a subject in need of treatment thereof, wherein the subject is at risk of having or the subject has already had a vascular event or suffering from an inflammatory disease or disorder. In one embodiment, the vascular event is a cardiovascular event (e.g., myocardial infarction). In another embodiment, the vascular event is a cerebrovascular event (e.g., stroke (such as transient ischemic attacks (TIAs)). In yet another embodiment the vascular event is a peripheral vascular event (e.g., intermittent claudication). The method comprises administering a therapeutically effective amount of at least one growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be coadministered with a second growth hormone secretagogue, HMG CoA reductase inhibitor, an ACAT inhibitor, a CETP inhibitor, an anti-inflammatory agent, an ACE inhibitor, a Beta blocker, a cholesterol absorption inhibitor, a nicotonic acid, a fabric acid derivative, a bile acid sequestering agent or a combination thereof.</p> |
申请公布号 |
WO2005097261(A1) |
申请公布日期 |
2005.10.20 |
申请号 |
WO2005US10927 |
申请日期 |
2005.03.30 |
申请人 |
REJUVENON CORPORATION;POLVINO, WILLIAM, J.;CARPI, DAVID, B.;SMITH, ROY, G. |
发明人 |
POLVINO, WILLIAM, J.;CARPI, DAVID, B.;SMITH, ROY, G. |
分类号 |
A61K31/454;A61K38/05;C07K5/065;C07K5/078;(IPC1-7):A61P9/00;A61P9/10;A61P29/00 |
主分类号 |
A61K31/454 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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