发明名称 |
IMPROVEMENTS IN POLYMER PARTICLES |
摘要 |
<p>A process for covalently binding a tagged protein to a polymer particle comprising: contacting a tagged protein with a chelating agent-polymer particle conjugate wherein said tag comprises at least two histidine residues and at least two lysine residues and said chelating agent is tridentate, tetradentate or pentadentate and comprises at least two carboxyl groups and is coordinated by Co<2+ >ions, to form particle-chelating agent Co<2+ >complex: contacting said complex with a carbodiimide; and optionally removing the Co<2+ >ions.</p> |
申请公布号 |
WO2005089933(A1) |
申请公布日期 |
2005.09.29 |
申请号 |
WO2005GB00991 |
申请日期 |
2005.03.17 |
申请人 |
DYNAL BIOTECH ASA;SONGE, PAAL;CAMPBELL, NEIL |
发明人 |
SONGE, PAAL |
分类号 |
B01J20/26;B01J20/32;B01J45/00;(IPC1-7):B01J20/26 |
主分类号 |
B01J20/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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