ADZYMES AND USES THEREOF

摘要

Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed "adzymes," comprising an address moiety and a catalytic domain. A preferred adzyme is one having a catalytic domain based on mesotrypsin (including functional fragments, derivatives, variants, homologs, and/or stabilized mutations thereof). Another preferred adzyme is one having a targeting moiety based on a protein scaffold, such a protein having an immunoglobulin-like fold.