发明名称 |
FUNCTIONAL METHOD FOR GENERATING OR SCREENING FOR LIGANDS WHICH MODULATE STEROID HORMONE RECEPTORS |
摘要 |
This application presents the discovery that the Vitamin D3 receptor (VDR), a member of the nuclear hormone ligand-activated receptor superfamily, interacts with a MNAR, a scaffolding protein. This interaction results in the formation of a ternary complex between VDR, MNAR, and the Src or PI3 kinase families of tyrosine kinases to mediate cell signaling, especially in osteoblast cells. |
申请公布号 |
WO2005084266(A2) |
申请公布日期 |
2005.09.15 |
申请号 |
WO2005US06406 |
申请日期 |
2005.02.28 |
申请人 |
WYETH;BARLETTA, FRANK;O'DONNELL, GREG;CHESKIS, BORIS, J. |
发明人 |
BARLETTA, FRANK;O'DONNELL, GREG;CHESKIS, BORIS, J. |
分类号 |
C07K7/06;G01N33/53;G01N33/567;G01N33/82 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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