发明名称 |
LACTAMS AS CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETIC INHIBITORS |
摘要 |
The present invention relates to inhibitors of post-proline cleaving enzyme, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention incorporate a lactam ring in the backbone of the inhibitors. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
|
申请公布号 |
CA2555961(A1) |
申请公布日期 |
2005.09.09 |
申请号 |
CA20052555961 |
申请日期 |
2005.02.23 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
LAI, HUNG-SEN;BACHOVCHIN, WILLIAM W.;WU, WENGEN |
分类号 |
C07D207/273;A61P3/00;C07D207/26;C07D487/10 |
主分类号 |
C07D207/273 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|