摘要 |
Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released. |
申请人 |
GENESIS RESEARCH AND DEVELOPMENT CORPORATION LIMITED;WATSON, JAMES, D.;MURISON, GREG, J.;GRIGOR, MURRAY, ROBERT;HAVUKKALA, ILKKA, JAAKKO;MUNRO, GRANT;ABERNETHY, NEVIN;WEBSTER, GILL |
发明人 |
WATSON, JAMES, D.;MURISON, GREG, J.;GRIGOR, MURRAY, ROBERT;HAVUKKALA, ILKKA, JAAKKO;MUNRO, GRANT;ABERNETHY, NEVIN;WEBSTER, GILL |