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发明名称
化学方法及中间物
摘要
一种制造可作为HMGCoA还原抑制剂之(E)–7–〔4–(4–氟苯基)–6–异丙基–2–〔甲基(甲磺醯基)胺基〕嘧啶–5–基〕(3R,5S)–3,5–二羟庚–6–烯酸之钙盐之方法,其系自式(7)之化合物,093132288-p01.bmp其中A系为缩醛或缩酮保护基团且R系为烷基,经由式(8)或式(10)之单离结晶化合物而进行,093132288-p02.bmp本发明亦说明式7、8和10之结晶中间物。093132288-p01.bmp
申请公布号
TW200523256
申请公布日期
2005.07.16
申请号
TW093132288
申请日期
2004.10.22
申请人
阿斯特捷利康股份有限公司;野义制药股份有限公司 SHIONOGI & CO., LTD. 日本
发明人
哲夫冈田;约翰 哈百瑞;大卫 多盟 派崔克 莱芬
分类号
C07D239/42;C07B41/04;A61K31/505;A61P9/10;A61P3/06
主分类号
C07D239/42
代理机构
代理人
陈长文
主权项
地址
英国
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