DI-ESTER PRODRUGS OF CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL APPLICATIONS
摘要
The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailbility and reduced toxicity, while maintaining anti-cancer activity.
申请公布号
WO2005062985(A2)
申请公布日期
2005.07.14
申请号
WO2004US43719
申请日期
2004.12.23
申请人
AMERICAN BIOSCIENCE, INC.;SOON-SHIONG, PATRICK;DESAI, NEIL P.;TAO, CHUNLIN;YU, CHENGZHI
发明人
SOON-SHIONG, PATRICK;DESAI, NEIL P.;TAO, CHUNLIN;YU, CHENGZHI
