| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicine inhibiting activity of luteinizing hormone releasing hormone (LHRH) as a remedy for sex steroid much related diseases. SOLUTION: Decapeptides and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups (which include furo-2-yl, isonicotinyl, nicotinyl, 2-quinolinecarbonyl, 3-quinolinecarbonyl, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl and tetrahydrofur-2-oyl) are potent antagonists of LHRH. The antagonists of LHRH are useful for suppressing the levels of sex hormones in mammals. COPYRIGHT: (C)2005,JPO&NCIPI
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