DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR CHEMR23 (CHEMR23)

摘要

The invention provides a human ChemR23 which is associated with the cardiovascular disorders, dermatological disorders, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, endocrinological diseases, gastroenterological diseases, metabolic diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, endocrinological diseases, gastroenterological diseases, metabolic diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of ChemR23 as well as pharmaceutical compositions comprising such compounds.