发明名称 |
Microarray hybridization device |
摘要 |
A novel hybridization device that improves the efficiency and consistency of microarray hybridization reactions by achieving a greater degree of internal mixing of target solution. The device provides a gasket-and-cover-type chamber wherein solution mixing is achieved by the creation of a multitude of microbubbles. One or more of the inner walls that define the chamber contain bubble-rupturing elements that extend into the chamber and terminate in sharp edges. They are typically located on opposite sides of a rectangular chamber and are pointed in a direction opposing bubble movement. Their interference with larger bubbles causes their breakup into microbubbles which travel separate and distinct paths as a result of external agitation and thereby provide improved solution mixing that results in a uniform distribution of target molecules to the probe molecules bound to the substrate. The sensitivity and consistency of the hybridization reaction is significantly increased.
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申请公布号 |
US2005112589(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
US20030722290 |
申请日期 |
2003.11.24 |
申请人 |
HAHN SOONKAP;STEADMAN JHOBE;TSINBERG PAVEL;WATANASKUL TIM;GERASSI YEHUDIT |
发明人 |
HAHN SOONKAP;STEADMAN JHOBE;TSINBERG PAVEL;WATANASKUL TIM;GERASSI YEHUDIT |
分类号 |
B01F9/00;B01F11/00;B01F13/00;B01F13/02;B01J19/00;B01L3/00;C12Q1/68;C40B60/14;G01N35/00;G01N35/02;(IPC1-7):C12Q1/68;C12M1/34 |
主分类号 |
B01F9/00 |
代理机构 |
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