发明名称 |
Alteration of sequence of a target molecule |
摘要 |
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that protein naturally produced from the target nucleic acid prior to splicing. The method includes contacting the target nucleic acid molecule with a catalytic nucleic acid molecule including the separate nucleic acid molecule. Such contacting is performed under conditions in which at least a portion of the separate nucleic acid molecule is spliced with at least a portion of the target nucleic acid molecule to form a chimeric nucleic acid molecule. In this method, the catalytic nucleic molecule is chosen so that it is not naturally associated with the separate nucleic acid molecule.
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申请公布号 |
US6897016(B1) |
申请公布日期 |
2005.05.24 |
申请号 |
US19980165514 |
申请日期 |
1998.10.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
SULLENGER BRUCE A.;CECH THOMAS R. |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12Q1/68;C12P19/34;C07H21/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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