发明名称 |
MULTIPARTICLE PHARMACEUTICAL DOSAGE FORM CONTAINING A MUCOADHESIVELY FORMULATED PEPTIDE OR PROTEIN ACTIVE SUBSTANCES METHOD FOR PRODUCING SAID PHARMACEUTICAL DOSAGE FORM |
摘要 |
The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 µm and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents. |
申请公布号 |
WO2005007139(A3) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004EP07882 |
申请日期 |
2004.07.15 |
申请人 |
ROEHM GMBH & CO. KG;LIZIO, ROSARIO;PETEREIT, HANS-ULRICH;ROTH, ERNA;DE ANDRES, INES;DAMM, MICHAEL |
发明人 |
LIZIO, ROSARIO;PETEREIT, HANS-ULRICH;ROTH, ERNA;DE ANDRES, INES;DAMM, MICHAEL |
分类号 |
A61K9/16;A61K9/26;A61K9/50;A61K38/00 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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