Mikanolide derivatives, their preparation and therapeutic uses

摘要

The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)₁ and (I)₂, wherein: R₁ represents H, SR₄ or NR₄R₅; R₂ represents SR₆ or NR₆R₇; R₃ represents OH, O(CO)R₁₄, OSiR₁₅R₁₆R₁₇, O(CO)OR₁₈ or O(CO)NHR₁₈, each of the radicals R₄, R₆, R₁₅, R₁₆ and R₁₇ representing independently (in particular) an alkyl radical, the radicals R₅ and R₇ representing (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals R₁₄ and R₁₈ representing independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I)₂, then R₁ does not represent a hydrogen atom