WATER-SOLUBLE MONO-PEGYLATED TETRAPYRROLE DERIVATIVES FOR PHOTODYNAMIC THERAPY AND METHOD OF PRODUCTION

摘要

Water-soluble mono-PEGylated tetrapyrrole derivatives are disclosed, having a formula given by formula (1), (2), or (3) in the specification. A method to produce the above water-soluble mono-PEGylated compounds is also disclosed, comprising an interaction of a tetrapyrrole with an aminopolyethylene glycol containing a functionalized terminal fragment, as well as their use as photosensitizers in photodynamic therapy.