COMPUESTO DERIVADO DEL ESTER DE 3,3-DIMETIL-4,4,7-TRIOXO-4-TIA-1-AZA-BICICLO [3.2.0]-HEPTANO-2-CARBOXILICO, COMPOSICION FARMACEUTICA, INHIBIDORES DE BETA LACTAMA, UTILES PARA TRATAR UNA INFECCION BACTERIANA.

摘要

Prodrugs of 6-beta-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, each X is methylene, and Y is O, or wherein R is H, each X is O and Y is methylene, and solvates thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention, or a solvate thereof, an optional beta-lactam antibiotic and at least one pharmaceutically acceptable carrier. Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof. Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.