发明名称 |
АНТАГОНИСТЫ СОМАТОСТАТИНА |
摘要 |
The present invention is directed to a method for synthesizing a peptide using solid-state chemistry in which at least one amide bond is N-methylated, wherein said method of synthesis utilizes N-Boc protected amino acids. For example, the a peptide is first synthesized using N-BOC protected amino acids and 4-methylbenzylhydrylamine functionalized 1% cross linked polystyrene resin until reaching the amide bond to be N-methylated. Then, the amino group at the desired methylation site is methylated. If desired, the synthesis of additional peptide using N-BOC protected amino acids may continued until the desired peptide is complete. |
申请公布号 |
RU2003129807(A) |
申请公布日期 |
2005.03.20 |
申请号 |
RU20030129807 |
申请日期 |
2002.03.05 |
申请人 |
ДЗЕ АДМИНИСТРЕЙТОРС ОФ ДЗЕ ТЬЮЛЕЙН ЭДЬЮКЕЙШНЛ ФАНД (US) |
发明人 |
КОЙ Дэвид Х. (US);МЕРФИ Вилль м А. (US);РАДЖЕСВАРАН Валаджапет Г. (US) |
分类号 |
C12N5/06;A61K38/04;A61K38/08;A61P3/00;A61P3/10;A61P5/02;A61P7/00;A61P9/00;C07K7/06;C07K7/64;C07K14/655 |
主分类号 |
C12N5/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|