发明名称 |
METHOD OF TREATMENT AND BIOASSAY INVOLVING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) AS CARDIAC-DERIVED MYOCARDIAL DEPRESSANT FACTOR |
摘要 |
<p>One embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount at least one anti-CD74 antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-TNFR antibody; a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Other embodiments of the present invention relate to methods of treating or preventing cardiac dysfunction, cardiodepression, burn injury-associated cardiac dysfunction, improving cardiac function in a subject following acute myocardial infarction, and identifying an MIF inhibitor.</p> |
申请公布号 |
WO2005020919(A2) |
申请公布日期 |
2005.03.10 |
申请号 |
WO2004US27945 |
申请日期 |
2004.08.30 |
申请人 |
CYTOKINE PHARMASCIENCES, INC.;BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GIROIR, BRETT;WILLIS, MONTE;DE LA CRUZ, VIDAL;SIELECKI, THAIS |
分类号 |
A61K;A61K39/395;C07K16/24;C07K16/28;(IPC1-7):A61K/ |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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