发明名称 |
Phosphatase associated with metastasis |
摘要 |
Among the genes identified, in a comparison of the global gene expression profile of metastatic colorectal cancer to that of primary cancers, benign colorectal tumors, and normal colorectal epithelium, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in non-metastatic tumors and normal colorectal epithelium. In three of twelve metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provides a new therapeutic target for these intractable lesions.
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申请公布号 |
US2005047996(A1) |
申请公布日期 |
2005.03.03 |
申请号 |
US20040868658 |
申请日期 |
2004.06.16 |
申请人 |
THE JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
VOGELSTEIN BERT;KINZLER KENNETH W.;SAHA SAURABH;BARDELLI ALBERTO |
分类号 |
G01N33/50;A61K39/00;A61K39/395;A61P35/00;C12N9/16;C12N15/09;C12Q1/42;C12Q1/68;G01N33/15;G01N33/543;G01N33/573;G01N33/574;(IPC1-7):A61K51/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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