AMINOPYRAZOLE COMPOUNDS AND USE AS CHK1 INHIBITORS

摘要

Described herein are aminopyrazole compounds of formula (I), wherein R<1>, R<2>, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.