Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists such as tetrazolyl or carboxylic acid derivatives

摘要

Disclosed is the use of a selective EP2 receptor agonist in the manufacture of a medicament for preventing bone loss and augmenting bone mass in a mammal. The medicament is also for enhancing bone healing facial reconstruction, maxillary reconstruction or mandibular reconstruction, enhancing long bone extension, enhancing the healing rate of a bone graft, enhancing prosthetic ingrowth and inducing vertebral synotosis in a mammal. Particular EP2 agonists disclosed are those of formula I, for which the substituents are defined herein.