| 摘要 |
This invention provides isolated nucleic acids of the rat and human p-Hyde gene, analogs, fragments, mutants and variants thereof of the p-Hyde family. The invention provides polypeptides, fusion proteins, chimerics, fusion proteins, antisense molecules, antibodies, and uses thereof. Also, this invention is directed to a method of inducing susceptibility to apoptosis with p-Hyde, a method of suppressing tumor growth with p-Hyde, and a method of treating a subject with cancer with p-Hyde alone or in combination with radiation, chemotherapy, or UV mimetic drugs. The invention also relates to the therapy of human cancers, which have a mutation in the p-Hyde gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates tot the screening of drugs for cancer therapy. Finally the invention relates to the screening o the p-Hyde gene for mutations, which are useful for diagnosing the predisposition to cancer.
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