摘要 |
Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
申请人 |
GENMAB A/S;VAN DE WINKEL, JAN, G., J.;VAN DIJK, MARCUS, ANTONIUS;SCHUURMAN, JANINE;GERRITSEN, ARNOUT, F.;BAADSGAARD, OLE, D., M., SC.;PETERSEN, JOERGEN |
发明人 |
VAN DE WINKEL, JAN, G., J.;VAN DIJK, MARCUS, ANTONIUS;SCHUURMAN, JANINE;GERRITSEN, ARNOUT, F.;BAADSGAARD, OLE, D., M., SC.;PETERSEN, JOERGEN |