MATRIX METALLOPROTEINASES INHIBITORS FOR THE STIMULATION AND PROTECTION OF BONE MARROW STEM CELLS

摘要

A method for the stimulation and/or protection of hemopoietic stem cells, characterized by treatment of said stem cells with a substance having an inhibitory activity against MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 defined as a) an IC50 value of less than 5 µM for MMP-2, MMP-9 and MMP-14 each; b) a ratio of more than 100 for the IC50 values of MMP-I:MMP-2, MMP-1: MMP-9, MMP­ I:MMP-14; and c) a ratio of more than 10 for the IC50 values of MMP-3:MMP-2, MMP-3: MMP-9, MMP-3:MMP-14.